Association Between Caseload Surge and COVID-19 Survival

Join NETEC and host Lauren Sauer as they welcome Dr. Sameer Kadri, author of the article "Association Between Caseload Surge and COVID-19 Survival in 558 U.S. Hospitals, March to August 2020," recently published in the Annals of Internal Medicine.

Dr. Kadri is an ICU physician and associate research physician at NIH. He serves as the head of the Clinical Epidemiology Section in the NIH Clinical Center's Critical Care Medicine Department.

In this episode of Transmission Interrupted, Dr. Kadri discusses his findings from a study that sought to understand the relationship between the COVID-19 surge and its impact on the mortality risk of patients admitted to these hospitals. Additional topics discussed in this episode include surge index, a metric designed to help measure the strain of hospital overcrowding.

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Guest

Sameer S. Kadri, MD, MS

Dr. Sameer S. Kadri is currently an associate research physician and head of the Clinical Epidemiology Section in the Clinical Center's Critical Care Medicine Department.

Dr. Kadri earned his degree in Medicine from the Seth G. S. Medical College and King Edward Memorial Hospital in Mumbai, India. He went on to complete internship and residency training in Internal Medicine at the New York-Presbyterian Hospital and Weill Cornell Medical Center and obtained a Masters degree in Clinical Epidemiology at the Harvard T.H. Chan School of Public Health.

Following his fellowship training in Critical Care Medicine at the NIH and in Infectious Diseases at Massachusetts General Hospital and Harvard Medical School, Dr. Kadri was appointed to Staff Clinician in the Critical Care Medicine Department at the NIH in 2014. In this role, he splits his time between attending in the Intensive Care Unit at the NIH Clinical Center, conducting clinical research and training clinical and research fellows in the Critical Care Medicine Department.

His primary research interest lies in infections in the critically ill. He leverages large datasets for epidemiologic investigations on antimicrobial resistance, sepsis, procalcitonin use, smoke inhalation acute lung injury and the role of IVIG in necrotizing fasciitis and granulocyte transfusions in invasive mycoses. His ongoing work includes use of large electronic health record-based repositories to understand the market size for new antibiotics (in collaboration with the US FDA), the impact of early discontinuation of antibiotics in culture negative sepsis and identify more objective candidate ICU performance measures.

He founded and leads the NIH Antimicrobial Resistance Outcomes Research Initiative (NIH–ARORI), a collaborative between the NIH Clinical Center, Intramural NIAID, the CDC and Harvard Medical School. Through this initiative he developed and tested a simple but clinically relevant bedside classification scheme for antimicrobial resistance called “Difficult-to-treat Resistance” or DTR that focuses on non-susceptibility to all first-line antibiotics. He is a peer reviewer for several subspecialty journals and has served as an editor for the Infectious Diseases Clinics of North America issue titled Complex Infectious Disease Issues in the Intensive Care Unit. He has spearheaded investigations that underscore the benefits of dually training in critical care medicine and infectious diseases and is promoting the unique role of critical care providers in combating antimicrobial resistance.

Host

Lauren Sauer, MSc

Lauren is an Associate Professor in the College of Public Health, Department of Environmental, Agricultural, and Occupational Health, at the University of Nebraska Medical Center and Core Faculty of the UNMC Global Center for Health Security. She is an Adjunct Associate Professor of Emergency Medicine in the Johns Hopkins School of Medicine, and the director of the Special Pathogens Research Network.

She previously served as Director of Operations for the Johns Hopkins Office of Critical Event Preparedness where she ran the inpatient COVID19 biobank and served on the COVID19 research steering committee for JHU. Lauren’s research focuses on human subjects research in bio-emergencies and disasters. Her work is focused on the ethical implementation of human subjects research and navigating the regulatory environment in disasters. Her research has focused on providing healthcare systems tools that facilitate implementation of policy requirements and clinical trials in emergencies.

Resources

Association Between Caseload Surge and COVID-19 Survival in 558 U.S. Hospitals, March to August 2020 https://www.acpjournals.org/doi/full/10.7326/M21-1213?journalCode=aim

NETEC COVID-19 Novel Coronavirus Resources: https://repository.netecweb.org/exhibits/show/ncov/ncov

NETEC COVID-19 Webinar Series Playlist: https://www.youtube.com/playlist?list=PL5JyGXQ8MP0TZXU2Ldy-jzjLuUNfFX8JZ

NETEC Resource Repository: https://repository.netecweb.org